coagulation factor VIIa

Function

• vitamin K-dependent serine protease
• proteolytically activates factor IX & factor X
• in the presence of tissue factor & Ca+2, factor VIIa then converts factor X to factor Xa by limited proteolysis
• factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor & Ca+2
• selective cleavage of Arg-|-Ile bond in factor X to form factor Xa

Pharmacology

• recombinant factor VIIa available under the names Niastase or Novoseven (Novo Nordisk)
• used for the treatment of bleeding episodes in hemophilia A or hemophilia B patients with antibodies to coagulation factor VIII or factor IX

More general terms

• coagulation factor
• serine protease trypsin family

More specific terms

• recombinant coagulation factor VIIa (Novo-Seven, rFVIIa, Niastase, Novo, Nordisk)

Additional terms

• coagulation cascade
• coagulation factor VII autoantibody
• coagulation factor VII; proconvertin; serum prothrombin conversion accelerator; SPCA; Eptacog alfa; contains: factor VII light chain; factor VII heavy chain (F7)