thromboplastin; tissue factor; TF; coagulation factor III; CD142 (F3)
Jump to navigation
Jump to search
Function
- membrane protein linked to either phosphatidyl ethanolamine or phosphatidylcholine
- binds factor VII or factor VIIa markedly increasing proteolytic activity of factor VIIa towards its primary substrate, factor X & factor IX
- initiates cell-surface assembly & propagation of the extrinsic coagulation cascade
Structure
belongs to the tissue factor family
Compartment
membrane
Expression
- expression is highly dependent upon cell type
- induced by inflammatory mediators interleukin 1 & TNF, as well as by endotoxin
- appears on surface of monocytes & vascular endothelial cells as a component of cellular immune response
More general terms
Additional terms
Component of
References
- ↑ Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 735
- ↑ Andrews BS. Is the WKS motif the tissue-factor binding site for coagulation factor VII? Trends Biochem Sci. 1991 Jan;16(1):31-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053135
- ↑ Fibrinolysis, Thrombosis, & Hemostasis: Concepts, Perspectives, & Clinical Applications. S Sherry, Lea & Febiger, Philadelphia, 1992, pg 76
- ↑ UniProt http://www.uniprot.org/uniprot/P13726.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/f3/ SHMPD; Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TF
- ↑ Wikipedia; Note: Tissue factor entry http://en.wikipedia.org/wiki/Tissue_factor