coagulation factor VII; proconvertin; serum prothrombin conversion accelerator; SPCA; Eptacog alfa; contains: factor VII light chain; factor VII heavy chain (F7)
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Function
- initiates the extrinsic pathway of blood coagulation
- serine protease that circulates in the blood in a zymogen form
- factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis
- in the presence of tissue factor & Ca+2, factor VIIa then converts factor X to factor Xa by limited proteolysis
- factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor & Ca+2
- selective cleavage of Arg-|-Ile bond in factor X to form factor Xa
- vitamin K-dependent, enzymatic carboxylation of some Glu allows the modified protein to bind Ca+2
- the iron & 2-oxoglutarate dependent 3-hydroxylation of Asp & Asn is (R) stereospecific within EGF domains
- heterodimer of a light chain & a heavy chain linked by a disulfide bond
Structure
- belongs to the peptidase S1 family
- contains 2 EGF-like domains
- contains 1 Gla (gamma-carboxy-glutamate) domain
- contains 1 peptidase S1 domain
Compartment
Alternative splicing
named isoforms=2; A,B
Expression
Pathology
- defects in F7 are the cause of factor VII deficiency
Pharmacokinetics
- 1/2life of 6 hours, shortest of coagulation factors[8]
1/2life = 6 hours
More general terms
Additional terms
Component of
- factor ix/factor vii/factor x/protein c/protein s/prothrombin
- prothrombin complex concentrate (Autoplex-T, Kcentra)
References
- ↑ UniProt http://www.uniprot.org/uniprot/P08709.html
- ↑ Wikipedia; Factor VII entry http://en.wikipedia.org/wiki/factor_VII
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/F7
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/f7/
- ↑ SHMPD; Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=F7
- ↑ Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053133
- ↑ Suttie JW. Synthesis of vitamin K-dependent proteins. FASEB J. 1993 Mar;7(5):445-52. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8462786
- ↑ 8.0 8.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
Database
- UniProt: http://www.uniprot.org/uniprot/P08709.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2155
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2155
- OMIM: https://mirror.omim.org/entry/227500
- UniProt: http://www.uniprot.org/uniprot/P08709.html