coagulation factor Xa

Function

• vitamin K-dependent serine protease
• proteolytically activates prothrombin in the presence of factor Va, Ca+2 & phospholipid during blood clotting
• selective cleavage of Arg-|-Thr & then Arg-|-Ile bonds in prothrombin to form thrombin

Pharmacology

• factor Xa inhibitors are used as anticoagulant in prophylaxis for venous thromboembolism

More general terms

• coagulation factor
• serine protease trypsin family

More specific terms

• recombinant factor Xa (Andexxa)

Additional terms

• coagulation cascade
• coagulation factor X; Stuart factor; Stuart-Prower factor; contains: factor X light chain; factor X heavy chain; activated factor Xa heavy chain (F10)
• coagulation factor Xa inhibitor