coagulation factor Va or accelerin

Function

• cofactor for the prothrombinase activity of factor Xa that results in activation of prothrombin to thrombin
• thrombin activates factor V proteolytically to the active cofactor, factor Va

Structure

• subunits factor Va heavy chain factor Va light chain, non-covalently bound
• interaction between the two chains is Ca+2-dependent

More general terms

• coagulation factor
• protease; proteinase; endopeptidase
• multisubunit protein

Additional terms

• coagulation cascade
• coagulation factor V; activated protein C cofactor; proaccelerin, labile factor; contains: coagulation factor V heavy chain; coagulation factor V light chain (F5)