thrombin; coagulation factor IIa

Function

• vitamin K-dependent serine protease form by proteolysis of prothrombin
• functions in blood homeostasis, inflammation & wound healing
• proteolytically activates
  • fibrinogen to fibrin
  • factor V to factor Va
  • factor VIII to factor VIIIa
  • factor XIII to factor XIIIa
  • in complex with thrombomodulin, protein C
  • platelet factor IIa
    • selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin & release fibrinopeptide A & fibrinopeptide B

More general terms

• serine protease trypsin family
• coagulation factor
• multisubunit protein

More specific terms

• thrombin topical (Recothrom)

Additional terms

• coagulation cascade
• proteinase-activated receptor 3; PAR-3; thrombin receptor-like 2; coagulation factor II receptor-like 2 (F2RL2, PAR3)
• prothrombin; coagulation factor II; contains: activation peptide fragment 1; activation peptide fragment 2; thrombin light chain; thrombin heavy chain (F2)
• thrombin receptor; proteinase-activated receptor 1; PAR-1; coagulation factor 2 receptor (F2R, CF2R, PAR1, TR)
• thrombin/thromboplastin (Thrombinar)

Component of

• calcium chloride/fibrinogen/fibrinolytic inhibitor/thrombin
• fibrinogen/thrombin
• fibrinogen concentrate/thrombin; fibrin sealant (Raplixa)
• thrombin/thromboplastin (Thrombinar)