thrombin receptor; proteinase-activated receptor 1; PAR-1; coagulation factor 2 receptor (F2R, CF2R, PAR1, TR)
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Function
- high affinity receptor for activated thrombin
- coupled to G proteins that stimulate phosphoinositide hydrolysis (Gi protein & Gp protein)
- may play a role in platelets activation & in vascular development
- thrombin specifically cleaves its receptor in an extracellular domain leading to self activation
- proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
- phosphorylated; probably mediating desensitization prior to the uncoupling & internalization of the receptor
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
cell membrane; multi-pass membrane protein
Expression
platelets & vascular endothelial cells
More general terms
More specific terms
Additional terms
- proteinase-activated receptor 3; PAR-3; thrombin receptor-like 2; coagulation factor II receptor-like 2 (F2RL2, PAR3)
- thrombin; coagulation factor IIa
References
- ↑ Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci. 1992 Oct;17(10):368-74. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1360717
- ↑ Marcus AJ, Safier LB. Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis. FASEB J. 1993 Apr 1;7(6):516-22. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8472890
- ↑ UniProt http://www.uniprot.org/uniprot/P25116.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/f2r/