rhoG proto-oncogene protein, G25K, Gp protein or CDC42Hs

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Function

  • growth-related protein
  • p21rho-G has relatively high intrinsic GTPase activity
  • dbl-protein facilitates ras GAP activity of p21rhoG
  • required for the formation of membrane ruffles during macropinocytosis
  • required for the formation of cup-like structures during trans-endothelial migration of leukocytes.
  • interacts with SGEF

Structure

belongs to the small GTPase superfamily, Rho family

Compartment

Pathology

More general terms

Component of

References

  1. UniProt http://www.uniprot.org/uniprot/P84095.html
  2. Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 1991 May 3;65(3):429-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/201897511
  3. Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
  4. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994 Jan 6;367(6458):40-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107774
  5. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=391

Database