rhoG proto-oncogene protein, G25K, Gp protein or CDC42Hs
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Function
- growth-related protein
- p21rho-G has relatively high intrinsic GTPase activity
- dbl-protein facilitates ras GAP activity of p21rhoG
- required for the formation of membrane ruffles during macropinocytosis
- required for the formation of cup-like structures during trans-endothelial migration of leukocytes.
- interacts with SGEF
Structure
belongs to the small GTPase superfamily, Rho family
Compartment
- cell membrane; lipid-anchor; cytoplasmic side (putative)
Pathology
- in case of Salmonella enteritidis infection, activated by SopB & SGEF, which induces cytoskeleton rearrangements & promotes bacterial entry
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P84095.html
- ↑ Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 1991 May 3;65(3):429-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/201897511
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994 Jan 6;367(6458):40-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107774
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=391