proteinase-activated receptor 3; PAR-3; thrombin receptor-like 2; coagulation factor II receptor-like 2 (F2RL2, PAR3)

Function

• receptor for activated thrombin
• coupled to G proteins that stimulate phosphoinositide hydrolysis
• interacts with INSC/inscuteable & probably GPSM2
• proteolytic cleavage generates a new N-terminus that functions as a tethered ligand

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• highest expression in the megakaryocytes of the bone marrow
• lower expression in mature megakaryocytes, platelets, heart, GI tract

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• thrombin receptor; proteinase-activated receptor 1; PAR-1; coagulation factor 2 receptor (F2R, CF2R, PAR1, TR)
• thrombin; coagulation factor IIa

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2151
• OMIM: https://mirror.omim.org/entry/601919
• UniProt: http://www.uniprot.org/uniprot/O00254.html