protein inscuteable homolog (INSC)

Function

• may function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex
• involved in spindle orientation during mitosis
• may regulate cell proliferation & differentiation in developing nervous system
• may play a role in asymmetric division of fibroblasts
• role in stratification of squamous epithelium (putative)
• interacts with ALS2CR19/PAR3-beta, F2RL2/PAR3, GPSM1/AGS3 & GPSM2/LGN

Compartment

• cytoplasm
• localizes to apical cortex of mitotic epidermal cells & to the apical side of neuronal progenitor cells (putative)

Alternative splicing

named isoforms=5

Expression

• isoform 1 is expressed in various tissues with stronger expression in liver, kidney & small intestine.
• isoform 2 is abundantly expressed in small intestine & to a lower extent in lung & pancreas
• expressed in fetal cochlea

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q1MX18.html