partitioning defective 3 homolog B; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein; PAR3-beta; partitioning defective 3-like protein; PAR3-L protein (PARD3B, ALS2CR19, PAR3B, PAR3L)

Function

• putative adapter protein involved in asymmetrical cell division & cell polarization processes
• may play a role in formation of epithelial tight junctions
• interacts with PARD6B. interacts with INSC/inscuteable

Structure

• the N-terminal part (1-351) part blocks the association of the tight junction marker TJP1 with the cell-cell boundary when it is overexpressed
• belongs to the PAR3 family
• contains 3 PDZ domain (DHR domain)s

Compartment

• endomembrane system
• cell junction, tight junction
• partially localized along the cell-cell contact region
• colocalizes with TJP1 to epithelial tight junctions

Alternative splicing

named isoforms=5

Expression

• highly expressed in kidney, lung & skeletal muscle
• expressed at intermediate levels in brain, heart, placenta, liver & pancreas
• isoform 1 is predominant isoform

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• amyotrophic lateral sclerosis (ALS); Lou Gerig's disease

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=117583
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:117583
• UniProt: http://www.uniprot.org/uniprot/Q8TEW8.html