partitioning defective 6 homolog beta (PAR-6 beta, PAR-6B, PARD6B, PAR6B)

Function

• adapter protein involved in asymmetrical cell division & cell polarization processes
• role in formation of epithelial tight junctions (putative)
• association with PARD3 may prevent interaction of PARD3 with F11R/JAM1 thus preventing tight junction assembly
• PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins
  • pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases
• interacts with GTP-bound forms of CDC42 & RAC1
• interacts with GTP-bound ARHQ/TC10
• interacts with MPP5 (putative)
• interacts with the N-terminal part of PRKCI & PRKCZ
• part of a complex with PARD3, CDC42 or RAC1 & PRKCI or PRKCZ
• part of a complex with LLGL1 & PRKCI
• interacts with ALS2CR19

Compartment

cytoplasm (putative)

Expression

• expressed in pancreas > placenta, lung
• not expressed in other tissues

More general terms

• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BYG5.html