tight junction protein ZO-1; zonula occludens protein 1; zona occludens protein 1; tight junction protein 1 (TJP1, ZO1)

Function

• N-terminal may be involved in transducing a signal required for tight junction assembly
• C-terminal may have specific properties of tight junctions
• alpha domain might be involved in stabilizing junctions
• interacts with HSPA4 & KIRREL1 (putative)
• homodimer, & heterodimer with TJP2/ZO-2 & TJP3/ZO-3
• interacts with occludin, claudins, CGN/cingulin, CXADR, GJA12, GJD3 & UBN1

Structure

• the 2nd PDZ domain mediates interaction with GJA12
• belongs to the MAGUK family
• contains 1 guanylate kinase-like domain
• contains 3 PDZ domain (DHR domain)s
• contains 1 SH3 domain
• contains 1 ZU5 domain

Compartment

• cell membrane; peripheral membrane protein, cytoplasmic side
• cell junction, tight junction
• movement of ZO-1 from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact

Alternative splicing

named isoforms=2; long, short

Expression

• the alpha-containing isoform is found in most epithelial cell junctions.
• the short isoform is found both in endothelial cells & highly specialized epithelial junctions of renal glomeruli & Sertoli cells of the seminiferous tubules

More general terms

• tight juntion protein or zona occludens protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7082
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7082
• OMIM: https://mirror.omim.org/entry/601009
• UniProt: http://www.uniprot.org/uniprot/Q07157.html