occludin (OCLN)

Function

• may play a role in the formation & regulation of the tight junction paracellular permeability barrier
• able to induce adhesion when expressed in cells lacking tight junctions
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with TJP1/ZO1 & with VAPA

Structure

• the C-terminal is cytoplasmic
  • important for interaction with ZO-1
  • sufficient for the tight junction localization
  • involved in the regulation of the permeability barrier function of the tight junction (putative)
• the first extracellular loop participates in an adhesive interaction belongs to the ELL/occludin family
• contains 1 MARVEL domain

Compartment

• membrane, cell junction, tight junction

Expression

• localized at tight junctions of both epithelial cells & endothelial cells
• highly expressed in kidney
• not detected in testis

More general terms

• phosphoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4950
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4950
• OMIM: https://mirror.omim.org/entry/602876
• UniProt: http://www.uniprot.org/uniprot/Q16625.html