RNA polymerase II elongation factor ELL; eleven-nineteen lysine-rich leukemia protein (ELL, C19orf17)
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Function
- transcription elongation factor
- can increase the catalytic rate of RNA polymerase 2 transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with EAF1 & EAF2
Structure
belongs to the ELL/occludin family
Compartment
- nuclear speckle, nucleus, Cajal body
- colocalizes with EAF2 to nuclear speckles
- also localized to Cajal (coiled) bodies
Expression
- expressed in all tissues tested
- highest levels found in placenta, skeletal muscle, testis & peripheral blood leukocytes
Pathology
- chromosomal translocation t(11;19)(q23;p13.1) involving ELL with MLL/HRX is found in acute leukemias
- the result is a rogue activator protein
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P55199.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/ELL.html