ELL-associated factor 2; testosterone-regulated apoptosis inducer & tumor suppressor protein (EAF2, TRAITS, BM-040)

Function

• transcriptional transactivator of TCEA elongation activity (putative)
• transcriptional transactivator of ELL & ELL2 elongation activities
• induces apoptosis in prostatic & non-prostatic cell lines
• inhibits prostate tumor growth in vivo.
• interacts with ELL, ELL2, TCEA1

Structure

belongs to the EAF family

Compartment

• nucleus; nucleoplasm, nuclear speckle
• colocalizes with ELL to nuclear speckles

Alternative splicing

named isoforms=2

Expression

• expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymphe node, spinal gland, stomach, thyroid, trachea, thymus, liver, leukocytes
• induction by androgen

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55840
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55840
• OMIM: https://mirror.omim.org/entry/607659
• UniProt: http://www.uniprot.org/uniprot/Q96CJ1.html