transcription elongation factor A protein 1; transcription elongation factor S-II protein 1; transcription elongation factor TFIIS.o (TCEA1 GTF2S TFIIS)

Function

• necessary for efficient RNA polymerase 2 transcription elongation past template-encoded arresting sites
• the arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes
• cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus
• S-II binds to RNA-polymerase II in the absence of transcription
• interacts with EAF2 (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the TFS-II family
• contains 1 TFIIS central domain
• contains 1 TFIIS N-terminal domain
• contains 1 TFIIS-type Zn+2 finger

Compartment

nucleus

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

Pathology

• chromosomal translocation t(3;8)(p21;q12) involving TCEA1 with PLAG1 may be a cause of salivary gland pleiomorphic adenomas

More general terms

• DNA-binding protein
• transcription elongation factor
• zinc finger protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6917
• OMIM: https://mirror.omim.org/entry/601425
• UniProt: http://www.uniprot.org/uniprot/P23193.html