serotransferrin; transferrin; Siderophilin; beta-1 metal-binding globulin (TF)
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Function
- beta-1 transferrin (aliases serotransferrin; siderophilin) is an iron transport sialoglycoprotein that shuttles iron between liver & tissues, especially bone marrow
- can bind 2 Fe+3 ions in association with the binding of an anion, usually bicarbonate
- serum transferrin may also have a further role in stimulating cell proliferation
Structure
- monomer
- beta-1 or serum transferrin contains 4 sialic acid groups which undergo partial desialization in CSF secondary to neuraminidase activity, producing beta-2 or tau transferrin, a cathodally migrating form of transferrin seen on high resolution CSF protein electrophoresis[1]
- belongs to the transferrin family contains 2 transferrin-like domains
Compartment
Expression
Pathology
- identification of beta-2 transferrin in nasal or aural fluid is specific for CSF leakage
- transferrin is a negative Acute Phase reactant
- low levels occur, along with low levels of albumin, prealbumin, & beta-lipoprotein, in inflammation & malignancy
- defects in transferrin are the cause of atransferrinemia
Polymorphism
- different polymorphic variants of transferrin are known
Laboratory
- transferrin carbodydrate deficient in CSF
- transferrin in serum
- transferrin in stool
- transferrin in urine
- transferrin gene mutation
More general terms
More specific terms
Additional terms
References
- ↑ 1.0 1.1 Zaret et al Clin Chem 38:1901 1992
- ↑ Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 711-713
- ↑ UniProt http://www.uniprot.org/uniprot/P02787.html
- ↑ Wikipedia: transferrin http://en.wikipedia.org/wiki/transferrin
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/tf/