beta 2 transferrin
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Structure
- desialated form of beta-1 transferrin
- beta-1 or serum transferrin contains 4 sialic acid groups which undergo partial desialization in CSF secondary to neuraminidase activity, producing beta-2 or tau transferrin, a cathodally migrating form of transferrin seen on high resolution CSF protein electrophoresis[1]
Pathology
- identification of beta-2 transferrin in nasal or aural fluid is specific for CSF leakage.
- apparently serum beta-2 transferrin is increased in alcoholism[2]
Laboratory
- serum protein electrophoresis:
- cathodally migrating form of transferrin seen on high resolution CSF protein electrophoresis[1]
- beta-2 transferrin in CSF
- beta-2 transferrin in serum