microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1, m-tau, mtau)

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Introduction

A family of microtubule-binding proteins

Classification

  • fetal (type I)
  • adult (type II)

Function

* Stimulation of the M1 receptor may diminish phosphorylation[7]

Structure

* fibrillogenic forms of tau have shorter half-lives than non-fibrillogenic forms[18]

Compartment

Alternative splicing

named isoforms=9 Additional isoforms seem to exist; isoforms differ from each other by the presence or absence of up to 5 of the 15 exons; one of these optional exons contains the additional tau/MAP repeat

Expression

Pathology

Laboratory

More general terms

More specific terms

Additional terms

References

  1. Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
  2. Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 1989 Oct;3(4):519-26. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2484340
  3. Goedert M. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci. 1993 Nov;16(11):460-5. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7507619
  4. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4137
  5. 5.0 5.1 5.2 5.3 Gamblin TC et al, Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A. Aug 19;100(17):10032-7. 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12888622
  6. 6.0 6.1 6.2 6.3 Horiguchi T et al, Nitration of tau protein is linked to neurodegeneration in tauopathies. Am J Pathol. 2003 Sep;163(3):1021-31. Erratum in: Am J Pathol. 2003 Dec;163(6):2645. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12937143
  7. 7.0 7.1 Mesulam M. The cholinergic lesion of Alzheimer's disease: pivotal factor or side show? Learn Mem. 2004 Jan-Feb;11(1):43-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14747516
  8. 8.0 8.1 Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal- regulated kinase: modulation by zinc. J Biol Chem. 2004 Oct 22;279(43):44795-801. Epub 2004 Aug 20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15322121
  9. 9.0 9.1 Arendt T. Neurodegeneration and plasticity. Int J Dev Neurosci. 2004 Nov;22(7):507-14. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15465280
  10. 10.0 10.1 10.2 10.3 Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. J Pathol. 2004 Nov;204(4):438-49. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15495240
  11. 11.0 11.1 11.2 11.3 11.4 11.5 Kosik KS, Shimura H. Phosphorylated tau and the neurodegenerative foldopathies. Biochim Biophys Acta. 2005 Jan 3;1739(2-3):298-310. Epub 2004 Nov 26. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15615647
  12. UniProt http://www.uniprot.org/uniprot/P10636.html
  13. Alzheimer research forum; Note: Tau mutations http://www.alzforum.org/res/com/mut/tau/default.asp
  14. Protein Spotlight; vita minima - Issue 68 of March 2006 http://www.expasy.org/spotlight/back_issues/sptlt068.shtml
  15. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAPT
  16. Wikipedia; Note: Tau protein entry http://en.wikipedia.org/wiki/Tau_protein
  17. 17.0 17.1 Yamada K et al Neuronal activity regulates extracellular tau in vivo. Journal of Experimental Medicine. JEM. Feb 17, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24534188 <Internet> http://jem.rupress.org/content/early/2014/02/11/jem.20131685.abstract
  18. 18.0 18.1 18.2 18.3 18.4 George J. Do Amyloid Plaques Drive Tau Deposition? New study ties tau production to amyloid burden. MedPage Today. March 21, 2018 https://www.medpagetoday.com/neurology/alzheimersdisease/71910
    Sato C, Barthelemy NR, Mawuenyega KG Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 97(6):1284-1298. March 21, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29566794 <Internet> http://www.cell.com/neuron/fulltext/S0896-6273(18)30136-3

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