muscarinic M1 receptor; muscarinic acetylcholine receptor M1 (CHRM1)
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Function
- role in breakdown of phosphoinositides & modulation of K+ channels through the action of G proteins
- the muscarinic M1 receptor is a post-synaptic receptor that appears to induce a facilitory response in post-synaptic neurons, perhaps contributing to learning & memory through facilitation of synaptic remodeling[3]
- the muscarinic M1 receptor is linked to cognition[5]
- as with other muscarinic receptors, the M1 receptor is a serpentine receptor transducing the binding of its ligand via intracellular G proteins
- it is linked to phosphatidylinositol (PI) turnover.
- interacts with GPRASP2
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Expression
- the muscarinic M1 receptor is the most abundant muscarinic receptor in the cerebral cortex
- also found in the dentate gyrus, hippocampus, anterior olfactory nucleus, olfactory tubercle & nucleus accumbens.
Pathology
- stimulation of the M1 receptor may diminish phosphorylation of microtubule associated protein tau, an initial step in the formation of paired helical filaments & neurofibrillary tangles associated with Alzheimer's disease[2]
- blockade of the M1 receptor causes typical anticholinergic effects:
- constipation
- blurred vision
- dry mouth
- drowsiness
More general terms
References
- ↑ Conkilin et al PNAS 85:8698 (1988)
- ↑ Jump up to: 2.0 2.1 Mesulam M. The cholinergic lesion of Alzheimer's disease: pivotal factor or side show? Learn Mem. 2004 Jan-Feb;11(1):43-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14747516
- ↑ Jump up to: 3.0 3.1 Greenfield's Neuropathology, 5th ed., 1992 p.1328
- ↑ UniProt http://www.uniprot.org/uniprot/P11229.html
- ↑ Jump up to: 5.0 5.1 Kwon D New schizophrenia drug could treat Alzheimer's disease. Nature News. 2024. Nov 21. https://www.nature.com/articles/d41586-024-03707-5?utm_source=Live+Audience&utm_campaign=1395f3bf68-nature-briefing-daily-20241121&utm_medium=email&utm_term=0_b27a691814-1395f3bf68-51070072
Tobin AB A golden age of muscarinic acetylcholine receptor modulation in neurological diseases. Nature Reviews Drug Discovery. 2024. 23:743-758 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39143241 https://www.nature.com/articles/s41573-024-01007-1