muscarinic M1 receptor; muscarinic acetylcholine receptor M1 (CHRM1)

Function

• role in breakdown of phosphoinositides & modulation of K+ channels through the action of G proteins
• the muscarinic M1 receptor is a post-synaptic receptor that appears to induce a facilitory response in post-synaptic neurons, perhaps contributing to learning & memory through facilitation of synaptic remodeling
• the muscarinic M1 receptor is linked to cognition
• as with other muscarinic receptors, the M1 receptor is a serpentine receptor transducing the binding of its ligand via intracellular G proteins
• it is linked to phosphatidylinositol (PI) turnover.
• interacts with GPRASP2

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane, cell junction, synapse
• postsynaptic cell membrane

Expression

• the muscarinic M1 receptor is the most abundant muscarinic receptor in the cerebral cortex
• also found in the dentate gyrus, hippocampus, anterior olfactory nucleus, olfactory tubercle & nucleus accumbens.

Pathology

• stimulation of the M1 receptor may diminish phosphorylation of microtubule associated protein tau, an initial step in the formation of paired helical filaments & neurofibrillary tangles associated with Alzheimer's disease
• blockade of the M1 receptor causes typical anticholinergic effects:
• constipation
• blurred vision
• dry mouth
• drowsiness

More general terms

• muscarinic receptor
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1128
• OMIM: https://mirror.omim.org/entry/118510
• UniProt: http://www.uniprot.org/uniprot/P11229.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1128