paired helical filament (PHF)

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Structure

* a constitutively activated form of CDK5/p23-35 may hyperphosphorylate tau

* glycogen synthase kinase 3-beta (GSK3-beta) has also been implicated in hyperphosphorylation of tau

Pathology

More general terms

Additional terms

References

  1. 1.0 1.1 Gray et al Neuropathol Appl Neurobiol 13:91 1987 (in dendrites)
  2. Mori et al Science 235:1641 1987
  3. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343
  4. Maccioni et al The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Archives of Medical Research 32:367, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11578751
  5. 5.0 5.1 Lee VM et al, Neurodegenerative tauopathies Annu Rev Neurosci 24:1121-59, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11520939
  6. 6.0 6.1 Friedhoff P, von Bergen M, Mandelkow EM, Mandelkow E. Structure of tau protein and assembly into paired helical filaments. Biochim Biophys Acta. 2000 Jul 26;1502(1):122-32. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10899437
  7. Gamblin TC et al, Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A. Aug 19;100(17):10032-7. 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12888622
  8. Ksiezak-Reding H, Wall JS. Characterization of paired helical filaments by scanning transmission electron microscopy. Microsc Res Tech. 2005 Jul;67(3-4):126-40. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16104001