dystrophic neurite
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Introduction
Dilated &/or tortuous neurites may be found within & immediately surrounding amyloid plaques. They may contain paired helical filaments. Tau-positive dystrophic neurites are also present in a more widespread distribution in the cortical neuropil apart from neuritic plaques. PHF- or tau-positive dystrophic neurites may be neuronal processes associated with neurons containing neuro- fibrillary tangles.
Some dystrophic neurites are immunoreactive for phosphorylated forms of neurofilament protein.
More general terms
Additional terms
- Alzheimer's disease (AD)
- amyloid (senile, neuritic) plaque
- microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1)
- neurofibrillary tangle (NFT)
- neurofilament protein
- paired helical filament (PHF)
References
- ↑ Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343