prefibrillar tau aggregate

^[1]

Structure

CSF phosphorylated serine-262 (p-tau262) & phosphorylated serine-356 (p-tau356) within a soluble tau assembly core identify prefibrillar tau aggregates^[1]

CSF prefibrillar tau aggregates identify Alzheimer pathology prior to formation of neurofibrillary tangles^[1]

↑ ^{Jump up to: 1.0} ^1.1 ^1.2 George J Alzheimer's Test Detects Tau Pathology Before Tangles Form. Detecting soluble tau assemblies early may improve Alzheimer's treatment outcomes. MedPage Today February 11, 2025 https://www.medpagetoday.com/neurology/alzheimersdisease/114181
Islam T, Hill E, Abrahamson EE et al Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease. Nat Med. 2025 Feb 10. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39930142 https://www.nature.com/articles/s41591-024-03400-0