glycogen synthase kinase 3 (GSK3)

Function

• hierarchical phosphorylation (see recognition motif, (@ is acidic residue)
• phosphorylates & inactivates factor involved in eIF-2 GDP/GTP-exchange activity
• GSK-3 is inactivated in response to insulin

More general terms

• proline-directed protein kinase

More specific terms

• glycogen synthase kinase 3-alpha (GSK3A)
• glycogen synthase kinase 3-beta (GSK3B)