glycogen synthase kinase 3-alpha (GSK3A)

Function

• implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB & the transcription factor JUN (putative)
• phosphorylates microtubule-associated protein tau
• appears to enhance APP-gamma secretase activity.
• inhibited by Li+

Structure

• monomer (putative)
• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
• contains 1 protein kinase domain

More general terms

• glycogen synthase kinase 3 (GSK3)

Database

• UniProt: http://www.uniprot.org/uniprot/P49840.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2931
• OMIM: https://mirror.omim.org/entry/606784
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2931