APP gamma-secretase

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Function

Structure

Compartment

More general terms

Additional terms

References

  1. 1.0 1.1 Ashall F, Goate AM. Role of the beta-amyloid precursor protein in Alzheimer's disease. Trends Biochem Sci. 1994 Jan;19(1):42-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8140621
  2. Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 2000 Jun 8;405(6787):689-94. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10864326
  3. Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature. 2000 Sep 7;407(6800):48-54. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10993067
  4. Marx J. Science 294:508, 2001
  5. 5.0 5.1 Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343
  6. Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature. 2003 Mar 27;422(6930):438-41. Epub 2003 Mar 16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12660785
  7. 7.0 7.1 De Strooper B, Annaert W. Where Notch and Wnt signaling meet. The presenilin hub. J Cell Biol. 2001 Feb 19;152(4):F17-20. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11266476
  8. Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J. 2002 Oct 15;21(20):5408-16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12374741
  9. Kimberly WT, Wolfe MS. Identity and function of gamma-secretase. J Neurosci Res. 74(3):353-60. 2003 Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14598311
  10. Wilson CA, Doms RW, Lee VM. Distinct presenilin-dependent and presenilin-independent gamma- secretases are responsible for total cellular Abeta production. J Neurosci Res. 74(3):361-9. 2003 Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14598312
  11. De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron. 2003 Apr 10;38(1):9-12. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12691659