Aph-1 protein or homolog of C. elegans anterior pharynx defective 1
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Function
- part of APP gamma-secretase complex
- APH1 stabilizes presenilin holoprotein in the complex
More general terms
More specific terms
- gamma-secretase subunit APH-1A (anterior pharynx defective 1 homolog A, presenilin stabilization factor, APH1A, PSF, CGI-78, UNQ579/PRO1141)
- gamma-secretase subunit APH-1B (anterior pharynx defective 1 homolog B, presenilin stabilization factor-like, Aph-1beta, APH1B, PSFL, UNQ688/PRO1328)
References
- ↑ Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature. 2003 Mar 27;422(6930):438-41. Epub 2003 Mar 16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12660785