gamma-secretase subunit APH-1B (anterior pharynx defective 1 homolog B, presenilin stabilization factor-like, Aph-1beta, APH1B, PSFL, UNQ688/PRO1328)

Function

• part of APP gamma-secretase complex
• probably present in a minority of gamma-secretase complexes compared to APH1A
• probably represents a stabilizing cofactor
• interacts with presenilin 1 & presenilin 2

Structure

belongs to the APH-1 family

Compartment

membrane (potential)

Expression

• weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart & brain

More general terms

• Aph-1 protein

Component of

• APP gamma-secretase

Database

• OMIM: https://mirror.omim.org/entry/607630
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8346
• UniProt: http://www.uniprot.org/uniprot/Q8WW43.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83464