amyloid-like protein 2; amyloid protein homolog; APPH; CDEI box-binding protein; CDEBP (APLP2, APPL2)

Function

• may play a role in the regulation of hemostasis
• the soluble form may have inhibitory properties towards coagulation factors
• may interact with cellular G-protein signaling pathways
• may bind to the DNA 5'-GTCACATG-3'(CDEI box)
• inhibits trypsin, chymotrypsin, plasmin, factor XIA & plasma & glandular kallikrein
• the BPTI - Kunitz inhibitor domain is O-glycosylated
• interacts with CPEB1 (putative)

Structure

• belongs to the APP family
• contains 1 BPTI - Kunitz inhibitor domain

Compartment

• cell membrane, nucleus (putative)

Alternative splicing

named isoforms=5 Additional isoforms seem to exist

Expression

• expressed in placenta, brain, heart, lung, liver, kidney & endothelial tissues

More general terms

• amyloid precursor like protein (APLP) family

Database

• UniProt: http://www.uniprot.org/uniprot/Q06481.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=334
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:334
• OMIM: https://mirror.omim.org/entry/104776