coagulation factor XIa

Function

• serine protease, proteolytically activates factor XII & prekallikrein
• factor XIa triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX
• selective cleavage of Arg-|-Ala & Arg-|-Val bonds in factor IX to form factor IXa

More general terms

• coagulation factor
• serine protease trypsin family

Additional terms

• coagulation cascade
• coagulation factor XI; FXI; plasma thromboplastin antecedent; PTA; contains: coagulation factor XIa heavy chain; coagulation factor XIa light chain (F11)