coagulation factor XI; FXI; plasma thromboplastin antecedent; PTA; contains: coagulation factor XIa heavy chain; coagulation factor XIa light chain (F11)
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Function
- precursor for coagulation factor XIa
- activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, & the heavy chain, which associates with high molecular weight (HMW) kininogen
- homodimer; disulfide-linked
- after activation the heavy & light chains are also linked by a disulfide bond
Structure
- belongs to the peptidase S1 family, plasma kallikrein subfamily
- contains 4 apple domains
- contains 1 peptidase S1 domain
Compartment
Alternative splicing
named isoforms=2
Expression
- isoform 2 is produced by platelets & megakaryocytes but absent from other blood cells
Pathology
- defects in F11 are the cause of factor XI deficiency
Laboratory
More general terms
More specific terms
Additional terms
- coagulation cascade
- coagulation factor XIa
- factor XI deficiency; plasma thromboplastin antecedent deficiency; Rosenthal syndrome
References
- ↑ UniProt http://www.uniprot.org/uniprot/P03951.html
- ↑ Wikipedia; Note: factor XI entry http://en.wikipedia.org/wiki/factor_XI
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/F11
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/f11/