coagulation factor XII; Hageman factor; HAF; contains: coagulation factor XIIa heavy chain; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa light chain (F12)
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Function
- factor XII is a serum glycoprotein that participates in initiation of blood coagulation, fibrinolysis, & the generation of bradykinin & angiotensin
- prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa & then trypsin cleaves it to beta-factor XIIa
- alpha-factor XIIa activates factor XI to factor XIa
- selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa & factor XI to form factor XIa
- factor XII is activated by kallikrein in alpha-factor XIIa, which is then further converted by trypsin into beta-factor XIIa
- alpha-factor XIIa is composed of the NH2-terminal heavy chain (coagulation factor XIIa heavy chain) & the COOH-terminal light chain (coagulation factor XIIa light chain), connected by a disulfide bond
- beta-factor XIIa is composed of 2 chains linked by a disulfide bond, a light chain (beta-factor XIIa part 2), corresponding to the COOH-terminal light chain (coagulation factor XIIa light chain) & a nonapeptide (beta-factor XIIa part 1)
Structure
- O- & N-glycosylated
- O-linked polysaccharides are probably the mucin type linked to galNAc
- belongs to the peptidase S1 family
- contains 2 EGF-like domains
- contains 1 fibronectin type-I domain
- contains 1 fibronectin type-II domain
- contains 1 kringle domain
- contains 1 peptidase S1 domain
Compartment
Pathology
- defects in F12 are the cause of factor XII deficiency
- defects in F12 are the cause of hereditary angioedema type 3
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P00748.html
- ↑ Wikipedia; Note: factor XII entry http://en.wikipedia.org/wiki/factor_XII
- ↑ F12base; Note: F12 mutation db http://bioinf.uta.fi/F12base/
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/f12/
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2161
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2161
- OMIM: https://mirror.omim.org/entry/234000
- OMIM: https://mirror.omim.org/entry/610618
- OMIM: https://mirror.omim.org/entry/610619
- UniProt: http://www.uniprot.org/uniprot/P00748.html