Kunitz-type serine protease inhibitor [KPI] domain

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Introduction

Kunitz-type serine protease inhibitor domain. Occurs in 751 & 771 amino-acid isoforms of the amyloid precursor protein (APP). In human platelets, this domain serves as an inhibitor of coagulation factor XIa.

More general terms

References

  1. ↑ Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343
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