amyloid-like protein 1; APLP-1; APLP; contains: C30 (APLP1)

Function

• may play a role in postsynaptic function
• the C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (putative)
• couples to JIP signal transduction through C-terminal binding
• may interact with cellular G-protein signaling pathways
• can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin & collagen-1
• the gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis (putative)
• proteolytically cleaved by caspases during neuronal apoptosis. cleaved, in vitro, at Asp-620 by caspase-3
• binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB & APBA family members, MAPK8IP1 & Dab1
• binding to Dab1 inhibits its Ser phosphorylation (putative)
• interacts with CPEB1
• binds Zn+2 & Cu+2 in the extracellular domain
• Zn+2-binding increases heparin binding
• No Cu+2 reducing activity with Cu+2-binding

Structure

• N-glycosylated & O-glycosylated
• the NPXY sequence motif found in many Tyr-phosphorylated proteins is required for the specific binding of the PID domain; however, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction
• the NPXY site is also involved in clathrin-mediated endocytosis
• belongs to the APP family

Compartment

• cell membrane
• C30: cytoplasm; C-terminally processed in the Golgi complex
• postsynaptic density

Expression

• expressed in the cerebral cortex where it is localized to the postsynaptic density

More general terms

• amyloid precursor like protein (APLP) family

Database

• UniProt: http://www.uniprot.org/uniprot/P51693.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=333
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:333
• OMIM: https://mirror.omim.org/entry/104775