disabled homolog 1 (DAB1)

Function

• adapter molecule functioning in neural development
• required for layering of neurons in cerebral cortex & cerebellum, along with reelin, VLDL receptor & apolipoprotein E receptor 2
• may regulate SIAH1 activity (putative)
• phosphorylated on Tyr-198 & Tyr-220 upon reelin induction in embryonic neurons (putative)
• also phosphorylated on Ser-524 independently of reelin signaling (putative)
• associates with the SH2 domains of SRC, FYN & ABL
• interacts with DAB2IP & SIAH1 (putative)
• interacts with LRP1

Structure

• PID domain specifically binds to Asn-Pro-Xaa-Tyr(P) motif found in many Tyr-phosphorylated proteins
• contains 1 PID domain

Alternative splicing

named isoforms=6

More general terms

• disabled homolog
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1600
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1600
• OMIM: https://mirror.omim.org/entry/603448
• UniProt: http://www.uniprot.org/uniprot/O75553.html