disabled homolog 2-interacting protein (DAB2-interacting protein, DAB2 interaction protein, ASK-interacting protein 1, DAB2IP, AF9Q34, AIP1, KIAA1743)
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Function
- Ras GTPase-activating protein
- on plasma membrane, exists in an inactive form complexed with TNFR1
- in response to TNF, dissociates from TNFR1 complex, tranlocates to cytoplasm & forms part of intracellular signaling complex comprising TRADD, RALBP1, TRAF2 & MAP3K5
- binding to MAP3K5 is induced by TNF
- preferentially binds Ser-966 dephosphorylated MAP3K5, & disrupts association of MAP3K5 with inhibitory 14-3-3 complex
- mediates TNF/TRAF2-induced MAP3K5-JNK activation
- inhibits CHUK-NF-kappa-B signaling
- tumor suppressor (putative)
- interacts with DAB1 & DAB2
Structure
- contains 1 C2 domain
- contains 1 PH domain
- contains 1 Ras-GAP domain
- C2 domain & Ras-GAP domain are required for interaction with MAP3K5
Compartment
Alternative splicing
named isoforms=3
Expression
- low expression in prostate
Pathology
- down-regulated in prostate cancer
- chromosomal translocation t(9;11)(q34;q23) involving DAB2IP with MLL is found in a patient with acute myeloid leukemia
- gives rise to a MLL-DAB2IP fusion protein lacking the PH domain (putative)
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q5VWQ8.html
- ↑ Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/AF9q34ID316.html