tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain (TRADD)
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Function
- adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD
- overexpression of TRADD leads to two major TNF-induced responses, apoptosis & activation of NF-kappa-B
- heterodimer with TNFRSF1A/TNFR1
- interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 & TRPC4AP
Structure
- requires the intact DEATH domain to associate with TNFRSF1A/TNFR1
- contains 1 death domain
Compartment
Expression
found in all examined tissues
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q15628.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/tradd/
- ↑ Hsu et al, The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81:495 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7758105
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8717
Database
- OMIM: https://mirror.omim.org/entry/603500
- UniProt: http://www.uniprot.org/uniprot/Q15628.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8717
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8717
- Kegg: http://www.genome.jp/dbget-bin/www_bget?