keratin, type 1 cytoskeletal 16; cytokeratin-16; CK-16; keratin-16; K16 (KRT16, KRT16A)

Introduction

heterodimer of a type I & a type II keratin. KRT16 associates with KRT6 isomers. interacts with TCHP. interacts with TRADD (putative)

Structure

belongs to the intermediate filament family

Expression

expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium & palmoplantar epidermis. also found in luminal cells of sweat & mammary gland ducts mass spec: mass=50924.66; method=MALDI; Range=2-473 Source=Pubmed:11840567

Pathology

• defects in KRT16 are a cause of
  • pachyonychia congenita type 1
  • unilateral palmoplantar verrucous nevus
  • palmoplantar keratoderma non-epidermolytic
• KRT16 & KRT17 are coexpressed only in pathological conditions including:
  • cervical metaplasia & cervical carcinoma
  • psoriasis vulgaris

More general terms

• cytokeratin, epithelial keratins or soft alpha-keratins

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3868
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3868
• OMIM: https://mirror.omim.org/entry/144200
• OMIM: https://mirror.omim.org/entry/148067
• OMIM: https://mirror.omim.org/entry/167200
• OMIM: https://mirror.omim.org/entry/600962
• UniProt: http://www.uniprot.org/uniprot/P08779.html