keratin, type 1 cytoskeletal 17; cytokeratin-17; CK-17; keratin-17; K17; p39.1 (KRT17)
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Function
- may play a role in the formation & maintenance of various skin appendages, specifically in determining shape & orientation of hair
- may be a marker of basal cell differentiation in complex epithelia
- required for the correct growth of hair follicles, in particular for the persistence of the anagen phase
- modulates function of TNF-alpha in the specific context of hair cycling
- regulates protein synthesis & epithelial cell growth through binding to the adapter protein SFN & by stimulating Akt/mTOR pathway
- involved in tissue repair
- KRT17 associates with KRT6 isomers
- interacts with TRADD & SFN
Structure
- type 1 cytokeratin
- heterodimer of a type 1 & a type 2 keratin
- belongs to the intermediate filament family
Compartment
Expression
- expressed in the outer root sheath & medulla region of hair follicle specifically from eyebrow & beard, digital pulp, nail matrix & nail bed epithelium, mucosal stratified squamous epithelia & in basal cells of oral epithelium, palmoplantar epidermis, sweat glands & mammary glands
- also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland & in exocervix (at protein level)
- induced in damaged or stressed epidermis
- induced by the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) & transforming growth factor-alpha (TGF-alpha), & by the NF-kappa B inhibitors Bay 11-7082 & Bay 11-7085
- down-regulated by antineoplastic agent Imatinib
Pathology
- defects in KRT17 are a cause of:
- KRT16 & KRT17 are coexpressed only in pathological conditions including:
- may act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells, thus causing their proliferation.
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q04695.html
- ↑ Human intermediate Filament mutation Database http://www.interfil.org
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRT17
- ↑ Wikipedia; Note: keratin-17 entry http://en.wikipedia.org/wiki/keratin_17
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3872
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3872
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3872
- OMIM: https://mirror.omim.org/entry/148069
- OMIM: https://mirror.omim.org/entry/167210
- OMIM: https://mirror.omim.org/entry/184500
- UniProt: http://www.uniprot.org/uniprot/Q04695.html