imatinib (Gleevec)

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Introduction

Tradename: Gleevec (imatinib mesylate), formerly STI571

Indications

* may be drug of choice for CML

Dosage

given PO QD

Monitor

* also see ARUP consult []

Adverse effects

* adverse effects severe enough to cause discontinuation of therapy in 2% of patients[2]

Mechanism of action

Notes

  • Manufacturer: Novartis
  • price tripled from $30,000 per year in the U.S. at its 2001 introduction to over $90,000 in 2012[8]

More general terms

References

  1. Prescriber's Letter 8(6):34 2001
  2. Jump up to: 2.0 2.1 2.2 Journal Watch 22(7):53, 2002 Kantarjian H et al, N Engl J Med 346:645, 2002 Savage DG & Antman KH, N Engl J Med 346:683, 2002
  3. Jump up to: 3.0 3.1 Journal Watch 21(9):72, 2001 Druker et al, N Engl J Med 344:1031, 2001 Druker et al, N Engl J Med 344:1038, 2001 Goldman & Melo, N Engl J Med 344:1084, 2001
  4. Jump up to: 4.0 4.1 Journal Watch 23(8):63-64, 2003 O'Brien SG et al, N Engl J Med 348:994, 2003 Pegg K & Mackinnon S, N Engl J Med 348:1048, 2003
  5. Department of Veterans Affairs, VA National Formulary
    restricted to hematology/oncology
  6. Jump up to: 6.0 6.1 FDA MedWatch http://www.fda.gov/medwatch/safety/2006/safety06.htm#Gleevec
  7. Jump up to: 7.0 7.1 7.2 Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260704&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. Jump up to: 8.0 8.1 Experts in chronic myeloid leukemia Price of drugs for chronic myeloid leukemia (CML), reflection of the unsustainable cancer drug prices: perspective of CML experts. Blood. April 15, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23620577 <Internet> http://bloodjournal.hematologylibrary.org/content/early/2013/04/23/blood-2013-03-490003.full.pdf+html
  9. Jump up to: 9.0 9.1 9.2 9.3 9.4 Medical Knowledge Self Assessment Program (MKSAP) 16, 18. American College of Physicians, Philadelphia 2012, 2018.
  10. Jump up to: 10.0 10.1 10.2 10.3 10.4 Deprecated Reference
  11. Jump up to: 11.0 11.1 He G, Luo W, Li P, Remmers C Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature. 2010 Sep 2;467(7311):95-8 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20811458
  12. Jump up to: 12.0 12.1 Spiera RF, Gordon JK, Mersten JN et al Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: results of a 1-year, phase IIa, single-arm, open-label clinical trial. Ann Rheum Dis. 2011 Jun;70(6):1003-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21398330
  13. ARUP Consult: Imatinib Therapeutic Drug Monitoring https://arupconsult.com/ati/imatinib-therapeutic-drug-monitoring

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