hepatotoxicity

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Introduction

Toxic to the liver.

Etiology

* most common culprits[2][4]

Epidemiology

Pathology

Complications

Differential diagnosis

Management

* other than acetaminophen

More general terms

More specific terms

Additional terms

References

  1. Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook, Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 829-39
  2. Jump up to: 2.0 2.1 2.2 Chalasani N et al. for the Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology 2008 Dec; 135:1924. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18955056
  3. Jump up to: 3.0 3.1 3.2 3.3 3.4 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018.
  4. Jump up to: 4.0 4.1 Bjornsson ES et al. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology 2013 Jun; 144:1419. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23419359
  5. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med. 2006 Feb 16;354(7):731-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16481640
  6. Jump up to: 6.0 6.1 Fontana RJ et al. Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset. Gastroenterology 2014 Jul; 147:96 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24681128
  7. Ghabril M, Chalasani N, Bjornsson E Drug-induced liver injury: a clinical update. Curr Opin Gastroenterol. 2010 May;26(3):222-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20186054
  8. Bjornsson E Review article: drug-induced liver injury in clinical practice. Aliment Pharmacol Ther. 2010 Jul;32(1):3-13 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20374223
  9. Verma S, Kaplowitz N. Diagnosis, management and prevention of drug-induced liver injury. Gut. 2009 Nov;58(11):1555-64. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19834119
  10. Lee WM, Hynan LS, Rossaro L et al Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology. 2009 Sep;137(3):856-64, 864.e1. Erratum in: Gastroenterology. 2013 Sep;145(3):695. Dosage error in article text. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19524577
  11. Chalasani NP, Hayashi PH, Bonkovsky HL et al ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2014 Jul;109(7):950-66; PMID: https://www.ncbi.nlm.nih.gov/pubmed/24935270
  12. Hoofnagle JH, Bjornsson ES. Drug-Induced Liver Injury - Types and Phenotypes. N Engl J Med 2019; 381:264-273, July 18 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31314970 https://www.nejm.org/doi/full/10.1056/NEJMra1816149
  13. Jump up to: 13.0 13.1 13.2 Torgersen J, Mezochow AK, Newcomb CW et al Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data. JAMA Intern Med. 2024 Jun 24:e241836. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38913369 PMCID: PMC11197444 Free PMC article. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2820267