hepatotoxicity

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Introduction

Toxic to the liver.

Etiology

* most common culprits[2][4]

Epidemiology

Pathology

Complications

Differential diagnosis

Management

* other than acetaminophen

More general terms

Additional terms

References

  1. Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook, Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 829-39
  2. 2.0 2.1 2.2 Chalasani N et al. for the Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology 2008 Dec; 135:1924. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18955056
  3. 3.0 3.1 3.2 3.3 3.4 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018.
  4. 4.0 4.1 Bjornsson ES et al. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology 2013 Jun; 144:1419. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23419359
  5. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med. 2006 Feb 16;354(7):731-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16481640
  6. 6.0 6.1 Fontana RJ et al. Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset. Gastroenterology 2014 Jul; 147:96 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24681128
  7. Ghabril M, Chalasani N, Bjornsson E Drug-induced liver injury: a clinical update. Curr Opin Gastroenterol. 2010 May;26(3):222-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20186054
  8. Bjornsson E Review article: drug-induced liver injury in clinical practice. Aliment Pharmacol Ther. 2010 Jul;32(1):3-13 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20374223
  9. Verma S, Kaplowitz N. Diagnosis, management and prevention of drug-induced liver injury. Gut. 2009 Nov;58(11):1555-64. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19834119
  10. Lee WM, Hynan LS, Rossaro L et al Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology. 2009 Sep;137(3):856-64, 864.e1. Erratum in: Gastroenterology. 2013 Sep;145(3):695. Dosage error in article text. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19524577
  11. Chalasani NP, Hayashi PH, Bonkovsky HL et al ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2014 Jul;109(7):950-66; PMID: https://www.ncbi.nlm.nih.gov/pubmed/24935270
  12. Hoofnagle JH, Bjornsson ES. Drug-Induced Liver Injury - Types and Phenotypes. N Engl J Med 2019; 381:264-273, July 18 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31314970 https://www.nejm.org/doi/full/10.1056/NEJMra1816149