prochlorperazine (Compazine, Stemetil, Novamin, Buccastem)

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Introduction

Tradename: Compazine.

Indications

Contraindications

  • children < 2 years of age

pregnancy category = c

safety in lactation = ?

Dosage

  • 5-10 mg IV over at least 2 min
  • 5-10 mg PO/IM TID/QID
  • 25 mg PR every 12 hours
  • pediatrics:
    • 0.4 mg/kg/day PO/PR divided TID-QID
    • 0.13 mg/kg/dose IM (IV not recommended)

Tabs: 5, 10, 25 mg.

Elixir: 5 mg/5 mL.

Suppositories: 2.5, 5, 25 mg.

Injection: 5 mg/mL (2 mL, 10 mL).

Sustained-release: (Compazine spansules)

  • 10 mg PO every 12 hours.
  • Tabs: 10, 15, 30 mg.

Pharmacokinetics

  • onset of action:
    • 30-40 minutes oral
    • 60 minutes rectal
    • 10-20 minutes IM
  • duration of action: 3-4 hours
  • eliminated primarily by hepatic metabolism & biliary secretion

elimination via liver

elimination via kidney

Adverse effects

Mechanism of action

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. AHFS 96 Drug Information, GK McEnvoy et al (ed), American Society of Health-System Pharmacists, Bethesda, MD 1996, pg 2135
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. 5.0 5.1 Braude D, Soliz T, Crandall C, Hendey G, Andrews J, Weichenthal L. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16490647
  6. 6.0 6.1 6.2 Deprecated Reference

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