dopaminergic receptor antagonist

Adverse effects

• acute effects
  • acute dystonia
    • often involves neck, face, larynx or eye
    • rapidly reversed with IV diphendydramine
  • acute akathisia
• late-appearing persistent effects (tardive syndromes)
  • tardive dyskinesia
  • tardive dystonia
    • often affects the face, neck, arms, trunk
  • tardive akathisia
• subacute or chronic
  • drug-induced parkinsonism
    • reversible with discontinuation of offending agent
• withdrawal syndromes
  • dystonia resolves within a few months
• neuroleptic malignant syndrome

• drug adverse effects of dopaminergic receptor antagonists
• drug adverse effects of antihypertensive agents

Notes

• dopmine D2 receptor antagonist

More general terms

• adrenergic receptor antagonist

More specific terms

• chlorpromazine (Thorazine, Ormazine, Propaphenin, Sonazine, Chloractil)
• clozapine (Clozaril)
• droperidol (Inapsine)
• fluphenazine (Prolixin, Anatensol, Triflumethazine, Calmansial, Modecate)
• haloperidol (Haldol, Halperon, Aloperidol, Halomonth)
• metoclopramide (Reglan, Metozolv ODT)
• olanzapine (Zyprexa, Zydis, Zyprexa, Relprevv)
• paliperidone (9-hydroxyrisperidone, Invega, Invega Sustenna)
• prochlorperazine (Compazine, Stemetil, Novamin, Buccastem)
• quetiapine (Seroquel)
• risperidone (Risperdal)
• sertindole (Serlect)
• thioridazine (Mellaril, Millazine, Melleretten)
• trifluoperazine (Stelazine, Suprazine)

Additional terms

• dopamine receptor