quetiapine (Seroquel)

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Introduction

Tradename: Seroquel. (quetiapine fumarate) Generic 2012[13]

Indications

Contraindications

Caution:

Dosage

  • initial dose 25 mg PO BID
  • usual effective oral dose 300-400 mg/day divided BID-TID
  • maximum dose: 750 mg QD
  • safety of doses > 800 mg/day has not been determined
  • up to 200 mg QD effective for agitation in the elderly

Tabs: 25 mg, 100 mg, 200 mg.

Dosage adjustment may be necessary with hepatic insufficiency.

Pharmacokinetics

protein binding = 83 %

1/2life = 6 hours

Monitor

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Micromedex
  3. Prescriber's Letter 7(8):45 200
  4. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 Prescriber's Letter 9(3):17 2002
  6. 6.0 6.1 Prescriber's Letter 10(11):62 2003
  7. 7.0 7.1 7.2 Journal Watch 25(12):96, 2005 Ballard C, Margallo-Lana M, Juszczak E, Douglas S, Swann A, Thomas A, O'Brien J, Everratt A, Sadler S, Maddison C, Lee L, Bannister C, Elvish R, Jacoby R. Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randomised double blind placebo controlled trial. BMJ. 2005 Apr 16;330(7496):874. Epub 2005 Feb 18. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15722369
    Gauthier S Drugs for Alzheimer's disease and related dementias. BMJ. 2005 Apr 16;330(7496):857-8. No abstract available. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15831849 <Internet> http://bmj.bmjjournals.com/cgi/content/full/330/7496/874
  8. 8.0 8.1 8.2 Prescriber's Letter 14(10): 2007 Quetiapine (Seroquel) abuse Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=231008&pb=PRL (subscription needed) http://www.prescribersletter.com
  9. Department of Veterans Affairs, VA National Formulary
  10. 10.0 10.1 Weeke P et al. Antipsychotics and associated risk of out-of-hospital cardiac arrest. Clin Pharmacol Ther 2014 Jun 24 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24960522
  11. 11.0 11.1 Correll CU et al Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents JAMA. 2009;302(16):1765-1773 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19861668 <Internet> http://jama.ama-assn.org/cgi/content/short/302/16/1765
    Varley CK & McClellan J Implications of Marked Weight Gain Associated With Atypical Antipsychotic Medications in Children and Adolescents JAMA. 2009;302(16):1811-1812 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19861677 <Internet> http://jama.ama-assn.org/cgi/content/short/302/16/1811
  12. 12.0 12.1 12.2 12.3 12.4 Revised quetiapine labeling - FDA July 2011 http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020639s049s054lbl.pdf
  13. 13.0 13.1 Prescriber's Letter 19(4): 2012 CHART: Anticipated Availability of First-Time Generics Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280401&pb=PRL (subscription needed) http://www.prescribersletter.com
  14. 14.0 14.1 Deprecated Reference
  15. 15.0 15.1 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
  16. 16.0 16.1 Cheslock M, Garry RT, Stewart JT Quetiapine Leads to Hyperosmolar Hyperglycemic State in a Nonagenarian. Annals of Long-Term Care 2022. March 4. https://www.hmpgloballearningnetwork.com/site/altc/case-report/quetiapine-leads-hyperosmolar-hyperglycemic-state-nonagenarian
  17. Mann JS, Ershadi M, Khan I, Saadabadi A Quetiapine National Library of Medicine, NCBI Bookshelf: StatPearls https://www.ncbi.nlm.nih.gov/books/NBK459145/
  18. Medscape: quetiapine (Rx) https://reference.medscape.com/drug/seroquel-xr-quetiapine-342984

Patient information

quetiapine patient information

Database