ziprasidone (Zeldox, Geodon)

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Indications

Contraindications

Dosage

  • start 20 mg PO BID with food
  • max 80 mg PO BID
  • no additional benefit observed for doses > 20 mg BID
  • IM dosing available

Tabs: 20, 40, 60 80 mg.

Injection: (Geodon IM)

Pharmacokinetics

elimination via liver

1/2life = 7 hours

protein binding = >99 %

Adverse effects

* higher risk of QT prolongation than other antipsychotics; little published data for use in elderly[8]

Overdose:

Drug interactions

Laboratory

Mechanism of action

Notes

Manufacturer: Pfizer

More general terms

Additional terms

References

  1. Prescriber's Letter 7(8):45 2000
  2. Prescriber's Letter 8(3):14 2001
  3. Prescriber's Letter 9(1):S1 2002
  4. Physicians Desk Reference (PDR) 56th ed, 2002
  5. Prescriber's Letter 9(8):45 2002
  6. 6.0 6.1 Prescriber's Letter 10(11):62 2003
  7. 7.0 7.1 Espinosa RT & Eslami MS, Clinical Geriatrics 12(1):45. 2004
  8. 8.0 8.1 8.2 8.3 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
  9. 9.0 9.1 FDA MedWatch. Dec 11, 2014 Ziprasidone (Marketed as Geodon and Generics): Drug Safety Communication - Rare But Potentially Fatal Skin Reactions. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm426624.htm
  10. Department of Veterans Affairs, VA National Formulary

Database