aldehyde oxidase (AOX1, AO)

Function

-..........-

an aldehyde + H2O + O2 <--> a carboxylic acid + H2O2

Cofactor:

• binds 2 2Fe-2S clusters
• FAD
• molybdopterin, molybdenum-binding protein

Structure

• homodimer
• belongs to the xanthine dehydrogenase family
• contains 1 2Fe-2S ferredoxin-type domain

Compartment

cytoplasm

Expression

• abundant in liver
• lower levels in lung, skeletal muscle, pancreas
• undetected in heart, brain & kidney

Notes

originally thought to be a xanthine dehydrogenase

More general terms

• aldehyde oxidoreductase
• metalloprotein

Additional terms

• molybdenum cofactor deficiency

Database

• UniProt: http://www.uniprot.org/uniprot/Q06278.html
• OMIM: https://mirror.omim.org/entry/252150
• OMIM: https://mirror.omim.org/entry/602841
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=316