drug-induced prolongation of the QT interval

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Etiology

* most common agents implicated in torsades de pointes

# amiodarone is rarely associated with torsades de pointes

More general terms

Additional terms

References

  1. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 151
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Jump up to: 3.0 3.1 3.2 3.3 3.4 Prescriber's Letter 8(4):19 2001
  4. Prescriber's Letter 11(11): 2004 Drugs That Prolong the QT Interval and/or Induce Torsades de Pointes Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=201115&pb=PRL Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=201111&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. Jump up to: 5.0 5.1 Prescriber's Letter 17(4): 2010 Drug-induced Long QT Interval CHART: Drug-induced Long QT Interval COMMENTARY: QT Prolongation, Torsades de Pointes, & Medication Safety Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260421&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. Prescriber's Letter 18(9): 2011 CHART: Drug-induced Long QT Interval COMMENTARY: QT Prolongation, Torsades de Pointes, & Medication Safety Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=270905&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. Prescriber's Letter 19(1): 2012 Drug-Induced Long QT Interval Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280111&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. Jump up to: 8.0 8.1 8.2 8.3 8.4 8.5 Geriatrics at your Fingertips, 13th edition, 2011 Reuben DB et al (eds) American Geriatric Society
  9. Jump up to: 9.0 9.1 Campbell N, Boustani MA, Ayub A, et al. Pharmacological management of delirium in hospitalized adults- a systematic evidence review. J Gen Intern Med 2009; 24:848-853 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19424763
  10. Jump up to: 10.0 10.1 10.2 Castro VM et al. QT interval and antidepressant use: A cross sectional study of electronic health records. BMJ 2013 Jan 29; 346:f288. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23360890
  11. Isbister GK, Page CB. Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice. Br J Clin Pharmacol. 2013 Jul;76(1):48-57 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23167578
  12. Wenzel-Seifert K, Wittmann M, Haen E. QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes. Dtsch Arztebl Int. 2011 Oct;108(41):687-93. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22114630 Free PMC Article
  13. CredibleMeds (MKSAP suggested reference) https://crediblemeds.org
  14. Jump up to: 14.0 14.1 Lou N Heart Groups: Clear Risks With HCQ for COVID-19 - AHA/ACC/HRS caution on malaria drug plus antibiotic. MedPage Today April 9, 2020 https://www.medpagetoday.com/infectiousdisease/covid19/85870
    Roden DM, Harrington RA, Poppas A, Russo AM. Considerations for drug interactions on QTc in exploratory COVID-19 (coronarvirus disease 2019) treatment. Circulation 2020. April 8 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32267732 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.047521
  15. Yap YG, Camm AJ. Drug induced QT prolongation and torsades de pointes Heart. 2003 Nov;89(11):1363-72 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14594906 PMCID: PMC1767957 Free PMC article
  16. Roden DM Drug-Induced Prolongation of the QT Interval N Engl J Med 2004;350:1013-22 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14999113 https://www.nejm.org/doi/pdf/10.1056/NEJMra032426
  17. Jump up to: 17.0 17.1 NEJM Knowledge+ Psychiatry