miconazole (Monistat, Lotrimin AF)

Introduction

Tradenames: Monistat, Lotrimin.

Indications

• oropharyngeal candidiasis
• treatment of vulvovaginal candidiasis (Monistat)
• treatment of athlete's foot (Lotrimin AF powder, spray)

Dosage

Tinea & Candida:

• 2% cream/powder/spray BID
• vaginal candidiasis: 1 200 mg vaginal suppository QHS for 3 days

Adverse effects

• common (> 10%)
  • fever/chills, rash, itching, anorexia, diarrhea, nausea/vomiting, pain at site of injection
• less common (1-10%)
  • anemia, thrombocytopenia
• uncommon (< 1%)
  • flushing of face & skin, drowsiness

Drug interactions

• rarely may significantly inhibit warfarin metabolism, increasing its anticoagulant effect

• drug interaction(s) of antibiotics with warfarin

Mechanism of action

• fungistatic

More general terms

• antifungal agent
• imidazole; glyoxaline; 1,3-diazole; iminazole

Additional terms

• candidiasis

Component of

• miconazole/salicylic acid
• chlorhexidine/miconazole
• miconazole/triclosan
• miconazole/nitrate/white petrolatum/zinc oxide
• miconazole/nitrate/polymixin b/prednisolone
• miconazole/nitrate
• dimethicone/miconazole/zinc oxide
• dimethicone/miconazole/nitrate/zinc oxide
• cortisol/miconazole/nitrate
• cortisol/gentamicin/miconazole
• chlorhexidine/miconazole/nitrate
• miconazole/white petrolatum/zinc oxide (Vusion)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4189
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=68553