donepezil (Aricept, Aricept ODT, Adlarity)

From Aaushi
Jump to navigation Jump to search

Introduction

Tradenames: Aricept, Aricept ODT.

Indications

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

  • start 5 mg PO QHS
  • may increase to 10 mg PO QHS in 4-6 weeks
  • average effective dose 5-10 mg PO QHS; 10 mg PO QHS[15]
  • may be better if given in AM
  • 23 mg dose
    • improvement over ARICEPT 10 mg on mental function, but not overall patient functioning[20]
    • increased adverse effects relative to 10 mg
    • patients should be on 10 mg of donepezil for at least 3 months before starting 23 mg dose[20]
  • taper recommended but no reference or rationale provided

Tabs: 5, 10, 23 mg. Aricept ODT[14]

Transdermal: Adlarity 5 mg/day, 10 mg/day, applied weekly[30]

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 70 hours

protein binding = 96 %

Adverse effects

(affected by rate of titration)

Drug interactions

Laboratory

Mechanism of action

Clinical trials

  • randomized, placebo-controlled, clinical trials of donepezil in vascular dementia[7][26]
    • study characteristics[7]
      • 24-week trial
      • 616 patients; mean age, 75.0 years
    • study characteristics[26]
      • 24-week trial conducted from March 2003 to August 2005
      • 974 patients; mean age, 73.0 years
    • results[7]
      • significant improvements in cognition & global function
    • results[26]

Notes

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Prescriber's Letter 7(2):10, Feb. 2000
  4. 4.0 4.1 Physician's Desk Reference (PDR) 56th edition, Medical Economics, 2002
  5. Role of cholinergic therapy in treatment of Alzheimer's disease & other dementias, Farlow, M et al, 2001
  6. Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
  7. 7.0 7.1 7.2 7.3 7.4 Journal Watch 23(20):159, 2003
    Wilkinson D, Doody R, Helme R et al Donepezil in vascular dementia: a randomized, placebo-controlled study. Neurology. 2003 Aug 26;61(4):479-86. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12939421
  8. R.S. Doody et al., Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease. Dement. Geriat. Cogn. Disord. 12 4 (2001), pp. 295-300 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11351141
  9. 9.0 9.1 Journal Watch 24(16):125-126, 2004 Courtney C for the AD2000 Collaborative Group Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial Lancet 363:2105, 2004 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15220031 <Internet> http://www.thelancet.com/journal/journal.isa
  10. 10.0 10.1 Salloway S, Ferris S, Kluger A, Goldman R, Griesing T, Kumar D, Richardson S; Donepezil 401 Study Group. Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial. Neurology. 2004 Aug 24;63(4):651-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15326237
  11. 11.0 11.1 Csernansky JG, Wang L, Miller JP, Galvin JE, Morris JC. Neuroanatomical predictors of response to donepezil therapy in patients with dementia. Arch Neurol. 2005 Nov;62(11):1718-22. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16286546
  12. 12.0 12.1 Howard RJ et al, Donepezil for the treatment of agitation in Alzheimer's disease. N Engl J Med 2007, 357:1382 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17914039
  13. Doody RS et al. Donepezil treatment of patients with MCI: A 48-week randomized, placebo-controlled trial. Neurology 2009 May 5; 72:1555. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19176895
  14. 14.0 14.1 14.2 Prescriber's Letter 17(9): 2010 COMMENTARY: New Dose of Aricept (Donepezil): 23 mg PATIENT HANDOUT: Cholinesterase Inhibitors for Dementia Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260905&pb=PRL (subscription needed) http://www.prescribersletter.com
  15. 15.0 15.1 15.2 15.3 15.4 15.5 15.6 15.7 Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
    Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
    Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019
    Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
  16. 16.0 16.1 16.2 16.3 16.4 Howard R et al Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease N Engl J Med 2012; 366:893-903March 8, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22397651 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1106668
    Schneider LS. Discontinuing donepezil or starting memantine for Alzheimer's disease. N Engl J Med. 2012 Mar 8;366(10):957-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22397659
    Burke D. ACP Journal Club. Donepezil or memantine improved cognitive functioning in moderate-to-severe Alzheimer disease (EDJ). Ann Intern Med. 19 June 2012; 156(12):JC6-JC10 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22711111
  17. Schwartz LM and Woloshin S. How the FDA forgot the evidence: The case of donepezil 23 mg. BMJ 2012 Mar 22; 344:e1086. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22442352
  18. Farlow MR, Salloway S, Tariot PN et al Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study. Clin Ther. 2010 Jul;32(7):1234-51. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20678673
    Farlow M1, Veloso F, Moline M, Yardley J et al Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease. BMC Neurol. 2011 May 25;11:57. doi:http://dx.doi.org/ 10.1186/1471-2377-11-57.
  19. Carrasco MM et al Safety and effectiveness of donepezil on behavioral symptoms in patients with Alzheimer disease. Alzheimer Dis Assoc Disord. 2011 Oct-Dec;25(4):333-40 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21399485
  20. 20.0 20.1 20.2 Sabbagh M, Cummings J, Christensen D et al Evaluating the cognitive effects of donepezil 23 mg/d in moderate and severe Alzheimer's disease: analysis of effects of baseline features on treatment response. BMC Geriatr. 2013 Jun 6;13:56 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23742728
    ARICEPT 23 mg vs. ARICEPT 10 mg http://www.aricept.com/aricept-5-10-23/aricept-23-vs-10
  21. Nguyen MD1, Salbu RL. Donepezil 23 mg: a brief insight on efficacy and safety concerns. Consult Pharm. 2013 Dec;28(12):800-3 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24322964
  22. 22.0 22.1 AGS Choosing Wisely Workgroup. American Geriatrics Society identifies another five things that healthcare providers and patients should question. J Am Geriatr Soc. 2014;62:950-960. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24575770
  23. 23.0 23.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
  24. 24.0 24.1 Burns A, Perry E, Holmes C et al A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease. Dement Geriatr Cogn Disord. 2011;31(2):158-64. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21335973
  25. 25.0 25.1 25.2 25.3 Molano JRV Does Stopping Donepezil for Alzheimer Disease Increase Nursing Home Placement? NEJM Journal Watch. Neurology Dec 2, 2016 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
    Howard R et al. Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: Secondary and post-hoc analyses. Lancet Neurol 2015 Oct 26 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26515660
  26. 26.0 26.1 26.2 26.3 Roman GC, Salloway S, Black SE et al Randomized, placebo-controlled, clinical trial of donepezil in vascular dementia: differential effects by hippocampal size. Stroke. 2010 Jun;41(6):1213-21. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20395618 Free PMC Article
  27. 27.0 27.1 Therapeutics Letter #108. Therapeutics Initiative Drugs to Avoid. http://www.ti.ubc.ca/2018/01/04/108-drugs-avoid/
  28. Jackson EG, Stowe S. Lesson of the month 1: prolonged QT syndrome due to donepezil: a reversible cause of falls? PMID: https://www.ncbi.nlm.nih.gov/pubmed/30651253 PMCID: PMC6399646 Free PMC article Clin Med (Lond). 2019;19(1):80-81 https://www.rcpjournals.org/content/clinmedicine/19/1/80
    Takaya T, Okamoto M, Yodoi K et al Torsades de Pointes with QT prolongation related to donepezil use. J Cardiol. 2009 Dec;54(3):507-11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19944332 Free article.
  29. 29.0 29.1 Soysal P, Isik AT, Stubbs B et al. Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2016 Dec;87(12):1368-1374 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27261502 https://jnnp.bmj.com/content/87/12/1368
  30. 30.0 30.1 Larkin HD First Donepezil Transdermal Patch Approved for Alzheimer Disease. JAMA. 2022;327(17):1642. May 3 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35503362 https://jamanetwork.com/journals/jama/fullarticle/2791713
    Adlarity - donepezil transdermal (Rx) https://reference.medscape.com/drug/adlarity-donepezil-transdermal-4000057
  31. 31.0 31.1 31.2 31.3 NEJM Knowledge+ Psychiatry
  32. 32.0 32.1 Arvanitakis Z, Shah RC, Bennett DA. Diagnosis and Management of Dementia: Review JAMA. 2019 Oct 22;322(16):1589-1599 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31638686 PMCID: PMC7462122 Free PMC article https://jamanetwork.com/journals/jama/fullarticle/2753376
  33. Sidhu S, Marine JE. Evaluating and managing bradycardia. Trends Cardiovasc Med. 2020;30:265-272. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31311698
  34. 34.0 34.1 Sutton SS, Magagnoli J, Cummings TH et al Alzheimer Disease Treatment With Acetylcholinesterase Inhibitors and Incident Age-Related Macular Degeneration. JAMA Ophthalmol. Published online January 4, 2024. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38175625 PMCID: PMC10767642 Free PMC article. https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2813353

Database